Apoptosis Inducing Factor |
| AIF Apoptosis Regulatory Protein; Apoptosis-Inducing Factor; Mitochondrial Apoptosis-Inducing Factor; Apoptosis-Inducing Factor, Mitochondrial; Mitochondrial Apoptosis Inducing Factor |
| A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation. |
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