Colorectal Neoplasms, Hereditary Nonpolyposis |
| Colon Cancer, Familial Nonpolyposis; Lynch Cancer Family Syndrome I; Lynch Syndrome I; Lynch Syndrome II; Syndrome, Lynch |
| A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. |
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