Complement C1 Inhibitor Protein definition

Complement C1 Inhibitor Protein
C1-INH Protein; C1-Inhibitor Protein; Complement C1-Inhibitor Protein; Plasma Protease C1 Inhibitor; C1 INH Protein; C1 Inhibitor Protein; Protein, C1-INH; Protein, C1-Inhibitor; Protein, Complement C1-Inhibitor
An endogenous serine protease inhibitor (SERPINS). It is a 105-kDA plasma glycoprotein, encoded by C1NH gene and produced primarily by the liver and monocytes. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from hereditary ANGIONEUROTIC EDEMA.