Core Binding Factor alpha Subunits definition

Core Binding Factor alpha Subunits
Acute Myeloid Leukemia Proteins; PEBP2A Transcription Factors; Polyomavirus Enhancer A Binding Protein 2; Polyomavirus Enhancer Binding Protein 2, Alpha Subunit; Runt Domain Factor; Runx Proteins; Transcription Factors, PEBP2A
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.