Cytochrome-B(5) Reductase |
| Methemoglobin Reductase; NADH Cytochrome B5 Reductase; NADH Methemoglobin Reductase; NADH-Cytochrome B5 Reductase; NADH-Ferrihemoglobin Reductase; B5 Reductase, NADH-Cytochrome; Methemoglobin Reductase, NADH; NADH Ferrihemoglobin Reductase |
| A FLAVOPROTEIN oxidoreductase that occurs both as a soluble enzyme and a membrane-bound enzyme due to ALTERNATIVE SPLICING of a single mRNA. The soluble form is present mainly in ERYTHROCYTES and is involved in the reduction of METHEMOGLOBIN. The membrane-bound form of the enzyme is found primarily in the ENDOPLASMIC RETICULUM and outer mitochondrial membrane, where it participates in the desaturation of FATTY ACIDS; CHOLESTEROL biosynthesis and drug metabolism. A deficiency in the enzyme can result in METHEMOGLOBINEMIA. |
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