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DNA Footprinting
DNA Footprint; DNA Footprintings; DNA Footprints; Footprint, DNA; Footprinting, DNA; Footprintings, DNA
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)