Dactinomycin |
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| Ac-De; Cosmegen; Cosmegen Lyovac; Lemery Brand of Dactinomycin; Lyovac-Cosmegen; MSD Brand of Dactinomycin; Merck Brand of Dactinomycin; Merck Frosst Brand of Dactinomycin; Merck Sharp & Dohme Brand of Dactinomycin; Lyovac, Cosmegen | |
| A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) | |