Didanosine |
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| Bristol-Myers Brand of Didanosine; Bristol-Myers Squibb Brand of Didanosine; NSC-612049; Videx; 2',3' Dideoxyinosine; Bristol Myers Brand of Didanosine; Bristol Myers Squibb Brand of Didanosine; NSC 612049; NSC612049 | |
| A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite. | |