Factor VIIIa |
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| Blood Coagulation Factor VIII, Activated; Activated Factor VIII; Factor VIII, Thrombin Activated; Factor VIIIa, Coagulation; Thrombin-Activated Factor VIII; VIIIa, Coagulation Factor | |
| Activated form of factor VIII. The B-domain of factor VIII is proteolytically cleaved by thrombin to form factor VIIIa. Factor VIIIa exists as a non-covalent dimer in a metal-linked (probably calcium) complex and functions as a cofactor in the enzymatic activation of factor X by factor IXa. Factor VIIIa is similar in structure and generation to factor Va. | |