Focal Adhesion Kinase 1 |
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| Endogenous Substrate pp120; Focal Adhesion-Associated Protein-Tyrosine Kinase pp125FAK; p125FAK Protein; Focal Adhesion Associated Protein Tyrosine Kinase pp125FAK | |
| A non-receptor protein tyrosine kinase that is localized to FOCAL ADHESIONS and is a central component of integrin-mediated SIGNAL TRANSDUCTION PATHWAYS. Focal adhesion kinase 1 interacts with PAXILLIN and undergoes PHOSPHORYLATION in response to adhesion of cell surface integrins to the EXTRACELLULAR MATRIX. Phosphorylated p125FAK protein binds to a variety of SH2 DOMAIN and SH3 DOMAIN containing proteins and helps regulate CELL ADHESION and CELL MIGRATION. | |