Medical.Webends.com - A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Genes, erbA
Genes, THRA; Genes, THRB; Genes, TR alpha; Genes, TR beta; Genes, erbA alpha; Genes, erbA beta; c-erbA Proto-Oncogenes; v-erbA Oncogenes; Gene, THRA; Gene, THRB; THRA Gene; THRA Genes; THRB Gene; THRB Genes; TR alpha Gene; TR alpha Genes; TR beta Gene
Genes related to the erbA DNA sequence that was first isolated from the avian erythroblastosis virus (ERYTHROBLASTOSIS VIRUS, AVIAN), v-erbA. In cells, erbA genes encode thyroid hormone receptors (RECEPTORS, THYROID HORMONE). Two distinct c-erbA genes have been identified: erbA-alpha located at 17q21; and erbA-beta located at 3p24. Truncations at the N- and C-terminals of erbA result in products resembling v-erbA. Truncations affect hormone responsiveness but not DNA binding capacity.