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Genes, erbB-1
Genes, erbB1; c-erbB-1 Proto-Oncogenes; v-erbB Oncogenes; EGFR Gene; Gene, erbB1; c erbB 1 Genes; c erbB 1 Proto Oncogenes; c-erbB-1 Gene; c-erbB-1 Proto-Oncogene; erbB 1 Genes; erbB-1 Gene; erbB1 Gene; erbB1 Genes; v erbB Genes; v erbB Oncogenes
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.