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Genes, erbB-2
Genes, HER2; Genes, erbb2; c-erbB-2 Proto-Oncogenes; Gene, HER2; Gene, erbb2; HER-2 Gene; HER-2 Genes; HER2 Gene; HER2 Genes; c erbB 2 Genes; c erbB 2 Proto Oncogenes; c-erbB-2 Gene; c-erbB-2 Proto-Oncogene; erbB 2 Genes; erbB-2 Gene; erbb2 Gene
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.