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Genes, sis
c-sis Proto-Oncogenes; sis Oncogene; v-sis Oncogenes; Gene, PDGFB; Gene, c-sis; Gene, sis; Gene, v-sis; Genes, c-sis; Genes, v-sis; Oncogene, sis; Oncogene, v-sis; Oncogenes, sis; Oncogenes, v-sis; PDGFB Gene; PDGFB Genes; Proto-Oncogene, c-sis
Retrovirus-associated DNA sequences (v-sis) originally isolated from the simian sarcoma virus (SSV). The proto-oncogene c-sis codes for a growth factor which is the B chain of PLATELET-DERIVED GROWTH FACTOR. v-sis or overexpression of c-sis causes tumorigenesis. The human sis gene is located at 22q12.3-13.1 on the long arm of chromosome 22.