HIV Envelope Protein gp120 |
| HIV Envelope Glycoprotein gp120; gp120 Envelope Glycoprotein, HIV; HIV 1 Envelope Protein gp120; HIV 2 Envelope Protein gp120; HTLV III gp120; gp120, HTLV-III |
| External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. It has a molecular weight of 120 kDa and contains numerous glycosylation sites. Gp120 binds to cells expressing CD4 cell-surface antigens, most notably T4-lymphocytes and monocytes/macrophages. Gp120 has been shown to interfere with the normal function of CD4 and is at least partly responsible for the cytopathic effect of HIV. |
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