Histiocytosis, Langerhans-Cell

Hand-Schueller-Christian Syndrome; Histiocytosis, Generalized; Histiocytosis-X; Letterer-Siwe Disease; Schueller-Christian Disease; Disease, Letterer-Siwe; Disease, Schueller-Christian; Generalized Histiocytoses; Generalized Histiocytosis
Group of disorders characterized by monoclonal proliferation of CD1+ HISTIOCYTES. The demonstration of the LANGERHANS CELLS Birbeck granules is the gold standard of the phenotype. EOSINOPHILIC GRANULOMA makes up 60-80% of all the cases.