Lymphoma, AIDS-Related

Lymphoma, AIDS-Associated; AIDS Associated Lymphoma; AIDS Related Lymphoma; AIDS-Associated Lymphomas; AIDS-Related Lymphomas; HIV Related Lymphoma; HIV-Related Lymphomas; Lymphoma, AIDS Associated; Lymphoma, AIDS Related; Lymphoma, HIV Related
B-cell lymphoid tumors that occur in association with AIDS. Patients often present with an advanced stage of disease and highly malignant subtypes including Burkitt lymphoma, immunoblastic large-cell lymphoma, small non-cleaved-cell lymphoma and diffuse large-cell lymphoma. The tumors are often disseminated in unusual extranodal sites and chromosomal abnormalities are frequently present. It is likely that polyclonal B-cell lymphoproliferation in AIDS is a complex result of EBV infection, HIV antigenic stimulation, and T-cell-dependent HIV activation.