Mannose-Binding Protein-Associated Serine Proteases definition

Mannose-Binding Protein-Associated Serine Proteases
MASP Proteases; MASP-Related Protein; MASPs; MBL-Associated Serine Proteases; MBP-Associated Serine Protease; MBP-Associated Serine Protease-Related Protein; Mannan-Binding Lectin Serine Proteases; Mannose-Binding Protein-Associated Serine Protease
Serum serine proteases which participate in COMPLEMENT ACTIVATION. They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). They cleave COMPLEMENT C4 and COMPLEMENT C2 to form C4b2a, the CLASSICAL PATHWAY C3 CONVERTASE.