Maturation-Promoting Factor |
| Histone H1 Kinase, Growth-Associated; Histone H1 Kinase, Growth Associated; Histone H1 Kinase, M Phase Specific; M Phase Promoting Factor; Maturation Promoting Factor; Mitosis Promoting Factor |
| Protein kinase that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2. |
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