NFATC Transcription Factors |
| NF-AT Proteins; NF-AT3 Protein; NF-AT4 Protein; NF-ATc1 Protein; NFAT Proteins; NFAT-1 Protein; NFAT-2 Protein; NFAT1 Protein; NFAT2 Protein; NFAT3 Protein; NFAT4 Protein; NFAT5 Protein; NFATC Proteins; NFATC1 Protein; NFATC1 Transcription Factor |
| A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2. |
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