Paraneoplastic Cerebellar Degeneration |
| Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndrome, Paraneoplastic; Paraneoplastic Cerebellar Syndrome; Anti Yo Associated Paraneoplastic Cerebellar Degeneration; Cerebellar Syndromes, Paraneoplastic |
| Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686) |
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