Phosphatidylinositol Diacylglycerol-Lyase

GPI-PLC; Glycosylphosphatidylinositol-Specific Phospholipase C; Monophosphatidylinositol Phosphodiesterase; Phosphatidylinositol-Glycan-Specific Phospholipase C; Phosphatidylinositol-Specific Phospholipase C; Phosphoinositide Phosphodiesterase C
A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a PHOSPHOLIPASE C. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.