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Phosphofructokinase-2
6-PF-2-K-Fru-2,6-P(2)ase; 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase; 6PF2K; ATP-D-Fructose-6-phosphate 2-phosphotransferase; F Kinase-F-bisphosphatase; Fru-6-P,2-kinase; Fru-kinase-Fru-bisphosphatase; Fructose 2,6-bisphosphatase
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.