Proteasome Endopeptidase Complex

20S Proteasome; Ingensin; Macropain; Macroxyproteinase; Multicatalytic Endopeptidase Complex; Multicatalytic Proteinase; Prosome; Proteasome; Complex, Multicatalytic Endopeptidase; Complex, Proteasome Endopeptidase; Endopeptidase Complex, Multicatalytic
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.