Proto-Oncogene Proteins c-abl
Proto-Oncogene Proteins abl; abl Proto-Oncogene Products; Products, abl Proto-Oncogene; Proteins abl, Proto-Oncogene; Proto Oncogene Proteins abl; Proto Oncogene Proteins c abl; Proto-Oncogene Products, abl; Proto-Oncogene Proteins, abl
Non-receptor tyrosine kinases encoded by the c-abl gene. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal hematopoiesis especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation.