Receptor, Epidermal Growth Factor |
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| Epidermal Growth Factor Receptor Kinase; Receptors, Epidermal Growth Factor; Epidermal Growth Factor Receptor Protein Tyrosine Kinase; Proto-Oncogene Protein, erbB-1; Receptor, TGF alpha; Receptor, Transforming Growth Factor alpha | |
| A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF related peptides including TRANSFORMING GROWTH FACTOR ALPHA, amphiregulin, and heparin-binding EGF-like growth factor. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell. | |