Receptor, IGF Type 1 |
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| IGF-1 Receptor; Insulin-Like-Growth Factor I Receptor; Receptor, IGF Type 1 alpha Subunit; Receptor, IGF Type 1 beta Subunit; Receptors, IGF-1; Receptors, Insulin-Like-Growth Factor I; IGF 1 Receptor; IGF I Receptor; IGF-1 Receptors | |
| A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precusor protein. The beta subunit contains an intrinsic tyrosine kinase domain. | |