Receptor, Serotonin, 5-HT1D |
| 5-HT(1D) Receptor; 5-HT(1Dalpha) Receptor; 5-HT1D Receptor; 5-HT1Dalpha Receptor; 5-Hydroxytryptamine1D Receptor; Receptor, Serotonin 1D; Receptor, Serotonin 1Dalpha; Serotonin 1D Alpha Receptor; Serotonin 1D Receptors; Serotonin 1Dalpha Receptor |
| A serotonin receptor subtype that is localized to the CAUDATE NUCLEUS; PUTAMEN; the NUCLEUS ACCUMBENS; the HIPPOCAMPUS, and the RAPHE NUCLEI. It plays a role as a terminal autoreceptor that regulates the rate of SEROTONIN release from nerve endings. This serotonin receptor subtype is closely related to and has similar drug binding properties as the 5-HT1B RECEPTOR, but is expressed at low levels. It is particularly sensitive to the agonist SUMATRIPTAN and may be involved in mediating the drug's antimigrane effect. |
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