Receptor, erbB-2 |
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| Oncogene Protein HER-2; Proto-Oncogene Proteins c-erbB-2; Receptors, erbB-2; p185(c-neu); HER 2 Proto Oncogene Protein; Oncogene Protein HER 2; Proto Oncogene Protein HER 2; Proto Oncogene Proteins c erbB 2; Proto-Oncogene Protein, HER-2 | |
| A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members. | |