Receptors, GABA-B |
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| Baclofen Receptor; GABA-B Receptor; Receptors, Baclofen; GABA B Receptor; GABA B Receptors; Receptor, Baclofen; Receptor, GABA-B; Receptors, GABA B | |
| Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and influence cells via interactions with G-proteins. GABA-B receptors are pharmacologically characterized by their insensitivity to the blocker bicuculline and sensitivity to the agonist L-baclofen. They are found both presynaptically and postsynaptically, and act variously by inhibition of adenylate cyclase, activation of phospholipase A2, activation of potassium channels, and inactivation of voltage-activated calcium channels. | |