Sirolimus |
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| AY 22-989; Rapamune; Wyeth Brand of Sirolimus; AY 22 989; AY 22989 | |
| A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. | |