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Sirtuins
NAD-Dependent Protein Deacetylases; Silent Mating Type Information Regulator 2-like Proteins; Sir2-like Deacetylases; Deacetylases, NAD-Dependent Protein; Deacetylases, Sir2-like; NAD Dependent Protein Deacetylases; Protein Deacetylases, NAD-Dependent
A homologous family of proteins that includes the NAD-dependent protein deacetylases which deacetylate proteins by catalyzing the formation of O-acetyl-ADP-ribose from the ADP-RIBOSE moiety (of NAD) and the acetyl group that is being removed from the protein. Sir2p, from Saccharomyces cerevisiae, is the founding member and the family includes other homologs (HSTs - homologs of Sir Two). Some HISTONE DEACETYLASES (the Sir2-like HDACs) belong to this family of proteins.