Simvastatin |
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| MK-733; Synvinolin; Zocor; MK 733; MK733 | |
| A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL-cholesterol (LIPOPROTEINS, LDL CHOLESTEROL). | |