Steroid 12-alpha-Hydroxylase |
| 12alpha-Hydroxylase; CYP8B1; Cytochrome P450 8B1; Cytochrome P450 CYP8B1; Steroid 12-Hydroxylase; Steroid-12-Hydroxylase; Steroid-12-Monooxygenase; Sterol 12 alpha-Hydroxylase; 12 alpha Hydroxylase; 12 alpha-Hydroxylase, Sterol; 12alpha Hydroxylase |
| A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol. |
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