eIF-2 Kinase |
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| DAI Protein Kinase; DSRNA-Dep Protein Kinase; Double Stranded RNA-Dependent Kinase (dsl); Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase; Eukaryotic Initiation Factor 2alpha Kinase; Heme Controlled Repressor; Heme-Controlled Inhibitor | |
| A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis. | |